Cationic Zinc What Is It? Numerous zinc supplementation trials have shown that a wide range of health benefits can be realized by increasing the intake of zinc where diets are inadequate in this micronutrient. Zinc ionophores are a chemical species that reversibly binds ions. Zinc ionophores lead to a rapid increase in intracellular zinc levels.
Zinc is a mineral once absorbed in the small intestine by a carrier-mediated mechanism. Once it has been absorbed it becomes Cationic Zinc in the fluids of the body.
Zinc is an essential component of a large number (>300) of enzymes participating in the synthesis and degradation of carbohydrates, lipids, proteins, and nucleic acids as well as in the metabolism of other micronutrients. Zinc stabilizes the molecular structure of cellular components and membranes and contributes in this way to the maintenance of cell and organ integrity. Furthermore, zinc has an essential role in polynucleotide transcription and thus in the process of genetic expression. Its involvement in such fundamental activities probably accounts for the essentiality of zinc for all life forms.
Cationic Zinc & Disease
Have you ever searched the relationship between cancer and zinc in PubMed? There are 15,879 publications, that should give some understanding that billions have been spent on research and understanding the relationship between Zinc, Biology, and Nature.
Zinc is one of the most important microelements necessary for normal body functioning. Zinc is marked in numerous diseases and, hence, its properties and behavior in the body have long been a subject of extensive study.
If you believe that your zinc levels in your blood provide the entire picture your wrong. Plasma zinc has a rapid turnover rate and it represents only about 0.l percent of total body zinc content.
Zinc is required in all body tissues and fluids. If you believe oral zinc supplementation will solve the problem your wrong. Lack of absorbency is the underlying problem.
Dr. Frederic E. Mohs was the developer of the idea of using zinc compositions topically as an anti-skin-cancer agent. In 1933, 23-year-old Frederic E. Mohs was a research assistant assigned to inject different chemicals into cancerous rat tissues to produce specific reactions. Today, the goal of Mohs’ surgery is to completely remove the tumor with maximum preservation of healthy tissue. It seems like now they forget the Zinc.
Disease Increases Zinc Deficiency
Despite decades of research, no efficacious chemotherapy exists for the treatment of prostate cancer. Malignant prostate zinc levels are markedly decreased in all cases of prostate cancer compared to normal/benign prostate. ZIP1 zinc transporter downregulation decreases zinc to prevent its cytotoxic effects. Thus, prostate cancer is a “ZIP1-deficient” malignancy. A zinc ionophore (e.g. Clioquinol) treatment to increase malignant zinc levels is a plausible treatment of prostate cancer.
However, skepticism within the clinical/biomedical research community impedes significant progress leading to such a zinc treatment. This report reviews the clinical and experimental background and presents new experimental data showing Clioquinol suppression of prostate malignancy; which provides strong support for a zinc ionophore treatment for prostate cancer. Evaluation of often-raised opposing issues is presented. These considerations lead to the conclusion that the compelling evidence dictates that a zinc-treatment approach for prostate cancer should be pursued with additional research leading to clinical trials.
Interesting Publication: Division of Urology, University of Maryland School of Medicine; Baltimore, USA
What are Zinc Ionophores?
A Zinc ionophore is a chemical species that reversibly binds ions, many antibiotics, particularly the macrolide antibiotics, are ionophores. Zinc ionophores lead to a rapid increase in intracellular zinc levels which in recent studies have shown these results.
- Zinc ionophores represent a powerful chemotype to induce cell death in cancer cells concurrently with a disruption in zinc homeostasis.
- Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections
- Zinc possesses anti‑inflammatory activity by inhibiting NF‑κB signaling and modulation of regulatory T‑cell functions that may limit the cytokine storm in COVID‑19.
- Zinc status is also tightly associated with risk factors for severe COVID-19 including aging, immune deficiency, obesity, diabetes, and atherosclerosis since these are known risk groups for zinc deficiency.
One of the most common trace-metal imbalances is elevated copper and depressed zinc. The ratio of copper to zinc is clinically more important than the concentration of either of these trace metals. Cu/ZnSOD1 is one of the three human superoxide dismutases identified and characterized in mammals.
When superoxide dismutase is diminished by the imbalance of zinc and copper the damage to cell membranes caused by superoxide radicals is increased.