Rhabdoid Tumor Treatment - A rhabdoid tumor is a rare and aggressive type of cancer. It most commonly affects children but can also occur in adults. Rhabdoid tumors are usually fast-growing and challenging to treat. They are often resistant to chemotherapy and radiation therapy. Surgery is often the only treatment option for rhabdoid tumors.
RRhabdoid tumors can occur in any body part, but they most commonly affect the brain, kidney, and liver. A rhabdoid tumor is also called an atypical teratoid rhabdoid tumor (ATRT brain cancer).
Rhabdoid kidney tumors are also called rhabdoid renal cell carcinomas (RCCs). Rhabdoid tumors are sporadic. They account for less than 1% of all childhood cancers.
Rhabdoid tumors are more common in children than adults. The average age at diagnosis is two years old. Children with rhabdoid tumors are often very ill and have a poor prognosis.
An atypical teratoid rhabdoid tumor is a very aggressive cancer that proliferates and can spread to other body parts. The average rhabdoid tumor cancer life expectancy is about 50%. ATRT brain cancer is often resistant to chemotherapy and radiation therapy.
The cause of rhabdoid tumors is unknown. However, researchers have identified a genetic mutation that may play a role in developing these tumors. The mutated gene is called the INI1 gene. This gene helps to control cell growth and division. The INI1 gene is located on chromosome 22. ATRT brain cancer occurs when the INI1 gene is mutated. This mutation causes the gene to stop working correctly, leading to uncontrolled cell growth and tumor development.
Rhabdoid tumors are not hereditary, meaning they cannot pass down from parents to children. However, families with a history of rhabdoid tumors may be at an increased risk of developing the condition.
Rhabdoid tumors are more common in males than females. Rhabdoid tumors occur more frequently in certain ethnic groups, such as African Americans and Hispanics.
Specific genetic mutations may increase the risk of developing rhabdoid tumors. The most common mutation is the INI1 gene mutation. This gene helps to control cell growth and division. Rhabdoid tumors occur when the INI1 gene is mutated.
Rhabdoid tumors that occur in the kidney can cause several symptoms, including:
Rhabdoid tumors that occur in the liver can cause several symptoms, including:
Rhabdoid tumors are very aggressive and difficult to treat. They are often resistant to chemotherapy and radiation therapy. Surgery for rhabdoid tumor treatment is regularly the only option. However, the tumor frequently grows so rapidly that surgery is not always viable. If surgery is possible, the goal is to remove as much of the tumor as possible.
There are several chemotherapy drugs that may be effective for treating rhabdoid tumors. These include:
These drugs are often used in combination with each other. Rhabdoid tumors often recur after treatment. The tumor may also become resistant to chemotherapy over time. Children with rhabdoid tumors regularly undergo radiation therapy. Radiation therapy may shrink the tumor before surgery or treat tumors that have recurred after treatment.
There is no cure for rhabdoid tumors. However, with treatment, some children can survive for numerous years. The average survival rate for children with rhabdoid tumors is about 50%.