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Metal Metabolism Uptake Creates More Accurate PET Scan for Cancer

March 10, 2022
Est. Reading: 3 minutes

What is a PET Scan for Cancer?

A PET scan is an oncologic imaging test that uses positron emission tomography to create images of the body. A PET scan can be used to diagnose cancer, help plan treatment, and monitor how well treatment is working.

The main purpose of a PET scan is to look for tumors in the body. Cancer cells often take up more sugar (glucose) than normal cells, so a PET scan can be used to find tumors. The images from a PET scan can also help doctors determine the size and location of a tumor.

In healthy states, metal homeostasis is tightly controlled, and its dysregulation is implicated as a cause or consequence of many human diseases. The study of trace metals in biology and medicine, historically known as inorganic biochemistry or bioinorganic chemistry, is becoming increasingly important and is now referred to as "metalomics".

metal metabolism

Homeostasis Definition

The term "homeostasis" was first coined in the 1930s by Walter Cannon, and it is defined as "the condition of steady internal environment necessary for the survival of cells and organisms". This means that homeostasis is the tendency of an organism or system to maintain equilibrium or a stable state.

Trace Metals in Cancer

The role of trace metals in cancer is complex and not fully understood. However, it is known that dysregulation of metal metabolism can lead to tumor formation and progression. For example, copper is essential for cell growth and proliferation, while zinc is necessary for DNA synthesis and repair. Therefore, changes in the levels of copper or zinc can have a significant impact on cancer cell growth.

 

Metal Metabolism Uptake Creates More Accurate PET Scan for Cancer

PET scans are based on the fact that cancer cells take up more sugar than normal cells. However, this is not the only difference between cancer cells and normal cells. Cancer cells also have a different metabolism than normal cells, and they often take up more trace metals.

In order for a PET scan to be more accurate, it is important that the patient's body has an adequate level of metal metabolism uptake. Metal metabolism uptake is the process by which the body takes up metals from the environment and uses them for various purposes, including creating enzymes that are necessary for life.

A recent study found that patients with cancer who had higher levels of metal metabolism uptake had more accurate PET scans. The study looked at 111 patients who were scheduled to have a PET scan to determine the stage of their cancer. The patients were divided into three groups based on their metal metabolism uptake levels.

metal homeostasis

The results of the study showed that the patients in the group with the highest metal metabolism uptake had the most accurate PET scans. The scans in this group were able to detect 91 percent of the tumors that were present. In contrast, the scans in the group with the lowest metal metabolism uptake were only able to detect 58 percent of the tumors.

These findings suggest that a patient's level of metal metabolism uptake may be an important factor in determining the accuracy of PET scanning for cancer. More research is needed to determine if this is true, but these results could have a significant impact on how PET scans are used to diagnose and treat cancer.

The role of trace metals in cancer is complex and not fully understood. However, it is known that dysregulation of metal metabolism can lead to tumor formation and progression. In order for a PET scan to be more accurate, it is essential that the patient's body has an adequate level of metal metabolism uptake.

We hope this information was helpful. For more information on cancer research, visit our blog!

 

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