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What is Carcinogenesis and Cell Transformation in Cancer

March 8, 2022
Est. Reading: 4 minutes

Carcinogenesis Meaning

The process of forming cancer is called carcinogenesis. Cells in your body naturally go through a process of change as they grow and divide. Sometimes, this process goes wrong, and cells grow out of control, creating a tumor.
Every day, your body encounters factors like radiation, ultraviolet light, and chemicals that can induce changes in your body's cells. Some of these exposures may increase the risk of cancer.


Whats carcinogen?

A carcinogen is a substance that can cause cancer. There are many different types of carcinogens, including:

  • Radiation: Ionizing radiation, such as X-rays and gamma rays, can damage DNA and cause cancer.
  • Ultraviolet light: Ultraviolet light from the sun can damage DNA and cause cancer.
  • Chemicals: Many everyday products, including cigarettes, asbestos, and benzene, contain carcinogens.
  • Viruses: Some viruses, such as HPV and hepatitis B, can cause cancer by damaging DNA.

Carcinogenesis and Oncogenesis

Carcinogenesis and oncogenesis are two different terms that people often use interchangeably. However, there is a difference between the two terms. Carcinogenesis refers to transforming normal cells into cancer cells, while oncogenesis relates to cancer development - Oncogenesis is the result of carcinogenesis. It is the final stage of the carcinogenic process when the cancer cells start to grow and spread uncontrollably.

carcinogenesis meaning

Cell Transformation in Cancer

Cancer begins with one or a few abnormal cells. If not destroyed, these cells can grow into a tumor. The transformation of normal cells into cancer cells is called carcinogenesis. Carcinogenesis involves transforming normal cells into cancer cells.
Carcinogenesis is a multi-step process that can take many years to complete. It involves the accumulation of genetic damage in cells, leading to cancer development.
The leading cause of carcinogenesis is DNA damage. DNA is the genetic material inside cells. It consists of chromosomes made up of DNA molecules. Chromosomes carry the genetic information that determines how a cell behaves.

The types of DNA damage that can lead to cancer include:

  • Mutations: Changes in the sequence of DNA molecules
  • Deletions: Loss of part of a chromosome
  • Duplications: Extra copies of a chromosome
  • Inversions: Rearrangement of the order of DNA molecules on a chromosome
  • Integrations: Insertion of foreign DNA into chromosomes

Scientists have intensively studied the cell cycle to help determine the cause of cancer. It has been going on for centuries, from Otto Warburg in the 1920s to a recent publication in 2014 with the new definition of Carcinogenesis, almost 100 years later. So now what?

Carcinogenesis is cancer's origin, production, or development through genotypic and phenotypic changes that upset the average balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over many years.

Year Carcinogenesis was introduced: 2014

Cell Transformation as a Neoplastic state is when the cell changes to a non-normal cell that has manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Year Cell Transformation was introduced: 1970 (1968)

Neoplasms are new abnormal growths of tissue. Malignant neoplasm cancers show a greater degree of anaplasia and have the properties of invasion and metastasis compared to benign neoplasms.

Year Neoplasms was introduced: 1964-1965

Carcinogenesis Steps

  • Carcinogenesis is a complex process, and many things can go wrong. The following are some of the most critical steps in the process:
  • Initiation: The first step is the initiation of cancer. 
  • It happens when cells exposed to a carcinogen cause permanent damage to their DNA.
  • Promotion: The second step is promotion. It occurs when the damaged cells start to divide and grow uncontrollably.
  • Progression: The third step is progression. It happens when the cancer cells spread to other parts of the body.


Types of Carcinogenesis

There are two types of carcinogenesis:

Initiation-promotion: The most common type of carcinogenesis involves the permanent damage to DNA that leads to the initiation of cancer, followed by promotion and progression.

Multistage process: This type of carcinogenesis occurs over a long period and involves the accumulation of several genetic changes in cells.

The answer today is the same as over 100 years ago, stop the cell transformation.

Cancer is a disease in which cells have lost their regular checks on cell proliferation.

By extension, it may not be surprising that tumor cells, to meet the increased requirements of proliferation, often display fundamental changes in energy metabolism pathways (The Krebs Cycle) and nutrient uptake (Minerals). Otto Warburg, a Nobel Prize winner, first proposed the theory in the 1920s that defects in energy metabolism, particularly in mitochondrial function, maybe the root cause of cancer. This theory, based on his findings, suggests that tumor cells preferentially use glycolysis over mitochondrial oxidative phosphorylation (OXPHOS) for glucose-dependent ATP production even in the presence of ample oxygen to fuel mitochondrial respiration, a phenomenon known as the “Warburg effect” (Warburg 1956).

So, if a new science delivered a natural method that improved the nutrient uptake in normal cells and killed non-normal cells, it would offer a solution. The CC Treatment works with the immune system, naturally with the help of science, determined by almost a century of study.

Learn More about the CC Treatment

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