The Statistics of Chemotherapy on Cancer

What are the statistics of chemotherapy? Chemotherapy is the treatment of cancer with one or more cytotoxic anti-neoplastic drugs. An older and broader use of the word chemotherapy encompassed any chemical treatment of disease, inhibiting cells, whether they be cancerous self cells or foreign cells such as bacteria. The general concept of this treatment has been used for 70 years originated by the effects of Mustard gas in World War 1 is now a multi billion dollar industry and the standard of care for cancer treatment.

The General Concept of Chemotherapy on Cancer Cells

Because cancer cells may grow and divide more rapidly than normal cells, chemotherapy is made to kill growing cells. Many normal, healthy cells also multiply quickly, and chemotherapy can affect these cells, too. This damage to normal cells causes side effects. The fast-growing, normal cells most likely to be affected are blood cells forming in the bone marrow and cells in the digestive tract (mouth, stomach, intestines, esophagus), reproductive system (sexual organs), and hair follicles. Chemotherapy may affect cells of vital organs, such as the heart, kidney, bladder, lungs, and nervous system.

In view of the minimal impact of cytotoxic chemotherapy on 5-year survival, and the lack of any major progress over the last 20 years, it follows that the main role of cytotoxic chemotherapy is in palliation. Although for many malignancies, symptom control may occur with cytotoxic chemotherapy, this is rarely reported and, for most patients, the survival in those who obtain a response is rarely beyond 12 months. The introduction of cytotoxic chemotherapy for solid tumors and the establishment of the sub-specialty of medical oncology have been accepted as an advance in cancer management. However, despite the early claims of chemotherapy as the panacea for curing all cancers, the impact of cytotoxic chemotherapy is limited to small subgroups of patients and mostly occurs in the less common malignancies.

cytotoxic chemotherapy, chemotherapy, risks, cancer, cancer treatment, cells

Even so, any new chemotherapy drug is still promoted as a major breakthrough in the fight against cancer, only to be later rejected without the fan fare that accompanied its arrival. In an environment of scarce resources and cost containment, there is a need for evidence-based assessment before any new or previously accepted treatment is accepted as standard practice. To justify the continued funding and availability of drugs used in cytotoxic chemotherapy, a rigorous evaluation of the cost-effectiveness and impact on quality of life is urgently required.

The Contribution of Cytotoxic Chemotherapy to 5-year Survival in Adult Malignancies

This study was presented by the Department of Radiation Oncology, Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, NSW; Department of Medical Oncology,
St Vincent’s Hospital, Sydney, NSW; Collaboration for Cancer Outcomes Research and Evaluation, Liverpool Health Service, Sydney, NSW, Australia

Common side effects of Chemotherapy

You may have none of these side effects or just a few. The kinds of side effects you have and how severe they are, depend on the type and dose of chemotherapy you get and how your body reacts.

  • Fatigue
  • Nausea & Vomiting
  • Pain
  • Hair Loss
  • Anemia
  • Infection
  • Blood Clotting Problems
  • Mouth, Gum and Throat Problems
  • Diarrhea and Constipation
  • Nerve and Muscle Effects
  • Effects on Skin and Nails
  • Radiation Recall
  • Kidney and Bladder Effects
  • Flu-Like Symptoms
  • Fluid Retention
  • Effects on Sexual Organs and Sexuality

Higher Risks of Cognitive Changes with Chemotherapy

Cognitive changes are sometimes related to higher dose chemotherapy and the use of immunotherapy to boost the immune system. Those who have cancer involving the brain may also experience cognitive changes as a result of the tumor or the treatment of the tumor. While cognitive changes associated with brain surgery often occur immediately, changes associated with radiation and chemotherapy can develop more gradually over time.

  • Tumor located in the central nervous system (CNS) which includes the brain and spinal cord.
  • Treatments administered directly to the CNS.
  • Treatments administered when extremely ill.
  • Chemotherapy and radiation given to the brain at the same time.
  • Chemotherapy given into the spinal fluid after radiation.

Some changes after cancer are very minor and will go away. Other cognitive changes may be more noticeable and may not be reversible.

Cognitive Changes with Chemotherapy

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4 Responses to The Statistics of Chemotherapy on Cancer

  1. Kenny T. says:

    Great article, chemo failed me four times before I was blessed enough to find out about cannabis oil treatments. I did have to travel to a different state to get the oil but well worth the trip. So blessed to be alive and plan on being around for many years to come.

  2. anton joseph says:

    Thank you for presenting this data and information.

  3. diane says:

    I have 2 more rounds of chemo, already have done 10…..I hate it, am I okay with denying the last 2, I want to start bldg my body back up.

  4. homeschool says:

    Great article. I am dealing with a few of these issues as well..

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